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Integrin antagonist conjugates for targeted delivery to cells expressing alpha-V-beta-3
专利权人:
发明人:
Robert Alan Goodnow, Jr.,Matthew Michael Hamilton,Agnieszka Kowalczyk,Achyutharao Sidduri
申请号:
US14374680
公开号:
US09586916B2
申请日:
2013.01.22
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The invention relates to compounds of formula (I): wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.
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http://www.ckcest.cn/home/
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