JO, JEONG HEIKR,조정희,YEO, JUN HWANKR,여준환,JUNG, WON SEOKKR,정원석,KANG, BYOUNG MANKR,강병만,JUNG, HO KYUNGKR,정호경,CHO, HYUN WOOKR,조현우,AN, BYEONG KWANKR,안병관
申请号：
KR1020140089744
公开号：
KR1020160009752A
申请日:
2014.07.16
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a composition comprising a wild Dendrobium moniliforme extract as an active ingredient for skin whitening and wrinkle alleviation and to a functional food and herbal cosmetics manufactured by using the composition. According to an embodiment of the present invention, the wild Dendrobium moniliforme extract shows an excellent effect on improvement in skin whitening due to an inhibitory effect of melanin synthesis, an inhibitory effect of tyrosinase activity, a reducing effect of tyrosinase protein expression, and a reducing effect of mRNA expression of TRP1, MITF, and TRP2. In addition, the wild Dendrobium moniliforme extract according to the present invention increases the biosynthesis rate of type 1 procollagen in fibroblasts derived from the human body, and has inhibited mRNA expression of MMP-1 and MMP-3 caused by TNF-a. Therefore, the composition according to the present invention can be practically used to manufacture a functional food and herbal cosmetics for skin whitening and wrinkle alleviation. The wild Dendrobium moniliforme extract is included at a concentration of 10-200 &mug/ml with respect to the total weight of the composition.COPYRIGHT KIPO 2016본 발명은 자생석곡 추출물을 유효성분으로 포함하는 미백 및 주름개선용 조성물, 및 이를 이용하여 제조되는 기능성 식품 및 한방 화장품에 관한 것으로서, 본 발명의 실시예에 의하면 자생석곡 추출물은 멜라닌 합성을 저해, 티로시나아제(tyrosinase) 활성도 저해, tyrosinase 단백질의 발현 감소 및 TRP1, MITF, TRP2 mRNA 발현 감소효과를 통해 미백 개선에 탁월한 효과를 보였으며, 또한 본 발명에 따른 자생석곡 추출물은 인체유래 섬유아세포에서 type 1 procollagen 생합성량을 증가시키고, TNF-a에 의한 MMP-1, MMP-3의 mRNA 발현을 억제시켰다. 따라서 본 발명에 따른 조성물은 미백 및 주름개선용 기능성 식품 및 한방화장품 제조에 유용하게 사용될 수 있다.
