A therapy system for use with a patient and a method of treating a medical condition of a patient. Electrical stimulation energy is delivered to a stimulation site on the wall of a blood vessel, thereby evoking at least one compound action potential in a nerve branch associated with the blood vessel. The evoked compound action potential(s) is sensed at a sensing site on the wall of the blood vessel. A circumferential location of the nerve branch is identified as being adjacent one of the stimulation site and the sensing site based on the sensed compound action potential(s). Ablation energy is delivered to an ablation site on the wall of the blood vessel adjacent the circumferential location of the nerve branch, thereby ablating the nerve branch and treating the medical condition.