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COMPOSITION PHARMACEUTIQUE COMPRENANT DE LA RAPAMYCINE OU UN DÉRIVÉ DE CELLE-CI
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
申请号:
EP16846489.9
公开号:
EP3351245A1
申请日:
2016.09.14
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
It is an object of the present invention to provide a pharmaceutical composition, which can suppress a reduction in the content of an active ingredient caused by oxidation or decomposition of rapamycin or a derivative thereof, can ensure long-term stability, and has high safety. In the present invention, the inventors have found that (B) a tocopherol derivative and (C) a phospholipid are used in a pharmaceutical formulation comprising rapamycin or a derivative thereof, so that oxidation or decomposition of the rapamycin or a derivative thereof can be suppressed, thereby completing the present invention. The rapamycin or a derivative thereof, and (B) the tocopherol derivative and (C) the phospholipid are preferably in the form of a solid mixture produced by preparing a solution containing these components and then removing the solvent from the solution.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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