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PKM2 activators for use in cancer treatment
专利权人:
Agios Pharmaceuticals; Inc.
发明人:
SALITURO, Francesco G.,SAUNDERS, Jeffrey
申请号:
ES10717982
公开号:
ES2619557T3
申请日:
2010.05.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound selected from formula (I) or formula (II): ** Formula ** where: m is an integer from 0 to 5; each R1 is independently selected from a group C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, halo, acetyl, -NO2, aryl, aralkyl, heteroaryl, -SO2-aryl, -C (O ) -NRb-aryl, -C (O) -aralkyl, -C (O) -C1-6alkoxy, - NRb-SO2-aryl, wherein each aryl, aralkyl, and heteroaryl is optionally substituted with 0-3 occurrences of Rc and wherein two R1 groups taken together with the carbon atoms to which they are attached form a heterocyclyl ring; n is an integer from 1 to 3; each R2 is independently selected from C1-C6 alkyl and halo; B is aryl, monocyclic heteroaryl, cycloalkyl, heterocyclyl, C1-6 aralkyl, or heteroaralkyl; L is a linker selected from -SO2-, -SO2NRa- and NRaSO2-; each Ra is independently selected from hydrogen and C1-C6 alkyl; where one of X and Y is O and the other is NRb or one of X and Y is S and the other is NRb; Z is O or S; each Rb is C1-C6 alkyl substituted with 0-1 occurrences of Rc; Rc is independently selected from C1-6alkyl, C1-6alkoxy, haloC1-6alkyl, halo, NRdRd, and heterocyclyl and wherein two Rc groups taken together with the carbon atoms to which they are attached form a heterocyclyl ring; and Rd is independently selected from H and C1-6 alkyl.Un compuesto seleccionado entre la fórmula (I) o la fórmula (II):**Fórmula** en donde: m es un número entero desde 0 a 5; cada R1 se selecciona independientemente entre un grupo alquilo C1-C6, alcoxi C1-C6, haloalquilo C1-C6, haloalcoxi C1-C6, halo, acetilo, -NO2, arilo, aralquilo, heteroarilo, -SO2-arilo, -C(O)-NRb-arilo, -C(O)-aralquilo, -C(O)-alcoxi C1-6, - NRb-SO2-arilo, en donde cada arilo, aralquilo y heteroarilo está opcionalmente sustituido con 0-3 ocurrencias de Rc y en donde dos grupos R1 tomados junto con los átomos de carbono a los que están unidos forman un anillo heterociclilo; n es un número entero desde 1 a 3; cada R2 se selecciona independientemente entre alquilo C1-C6 y h
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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