The described invention provides delivery systems, compositions and methods for reducing incidence or severity of atrial fibrillation in a subject at risk thereof, the method comprising providing a delivery system in a form that is malleable comprising a particulate formulation containing a plurality of particles comprising a therapeutic amount of an anti-arrhythmic agent and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the therapeutic agent is effective to reduce the incidence or severity of atrial fibrillation.
