PROBLEM TO BE SOLVED: To provide an isolated anti-EphB4 antibody.SOLUTION: According to the present invention, there is provided an isolated anti-EphB4 antibody comprising: (a) HVR-L1 including sequence A1-A11, the A1-A11 being RASQDVSTAVA (SEQ ID NO: 9)； (ii) HVR-L2 including sequence B1-B7, the B1-B7 being SASFLYS (SEQ ID NO: 11 ) (iii) HVR-L3 including sequence C1-C9, the C1-C9 being QESTTTPPT (SEQ ID NO: 15) ； and (iv ) HVR-H1 including sequence D1-D10, the D1-D10 is GFSISNYYLH (SEQ ID NO:2), etc.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】単離された抗ＥｐｈＢ４抗体を提供すること。【解決手段】上記単離された抗ＥｐｈＢ４抗体は、以下：（ａ）以下：（ｉ）配列Ａ１－Ａ１１を含むＨＶＲ－Ｌ１、ここでＡ１－Ａ１１はＲＡＳＱＤＶＳＴＡＶＡ（配列番号９）であるもの、（ｉｉ）配列Ｂ１－Ｂ７を含むＨＶＲ－Ｌ２、ここでＢ１－Ｂ７はＳＡＳＦＬＹＳ（配列番号１１）であるもの、（ｉｉｉ）配列Ｃ１－Ｃ９を含むＨＶＲ－Ｌ３、ここでＣ１－Ｃ９はＱＥＳＴＴＴＰＰＴ（配列番号１５）であるもの、（ｉｖ）配列Ｄ１－Ｄ１０を含むＨＶＲ－Ｈ１、ここでＤ１－Ｄ１０はＧＦＳＩＳＮＹＹＬＨ（配列番号２）であるもの、などを含む。【選択図】なし
