THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION; RENO;THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO;KOZEL, Thomas; ON BEHALF OF THE UNIVERSITY OF NEVADA;AUCOIN, David
发明人:
KOZEL, Thomas,AUCOIN, David
申请号：
USUS2011/032155
公开号：
WO2011/130301A9
申请日:
2011.04.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Non-invasive methods are provided herein for the diagnosis of melioidosis with specific antibodies capable of detecting molecules associated with melioidosis in a biological fluid, such as urine or serum. These molecules can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay. Methods of inducing an immune response to melioidosis are also disclosed. The methods include the use of the immunogenic melioidosis polypeptides, nucleic acids encoding these polypeptides, and/or viral vectors encoding an immunogenic melioidosis polypeptide, alone or in conjunction with other agents, such as traditional melioidosis therapies. Also disclosed are methods for treating a subject having melioidosis. These methods include inducing an immune response to melioidosis and/or using an inhibitory nucleic acid, such as a siRNA or antisense molecule, to decrease a melioidosis associated molecule expression in order to treat melioidosis.
