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Compuestos heterocíclicos para el tratamiento de trastornos neurológicos y psicológicos
专利权人:
Alkermes Pharma Ireland Limited
发明人:
REMENAR, Julius,BLUMBERG, Laura,ZEIDAN, Tarek
申请号:
ES10792677
公开号:
ES2639065T3
申请日:
2010.06.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound represented by Formula V, XVIII, X or XIII: ** ** Formula or its geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts solvates thereof, in which ** Image ** represents a single bond or double w is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11. R5 is selected from -CH (R10) C (O) OR20, -CH (R10) -C (O ) R20, -CH (R10) -OC (O) NR20R21, - (CH (R10)) - OPO3MY, - (CH (R10)) - OP (O) (OR20) (OR21), ** ** in Formula z is 1, 2, 3, 4, 5, 6 or 7 each R20 and R21 is independently selected from hydrogen, aliphatic, substituted aliphatic, aryl or substituted aryl Y and M are identical or different and each is a monovalent cation or M and Y are together a divalent cation each y is independently an integer between 0 and 30, in which R100, R101 and R103 are independently selected from hydrogen, halogen, C1-C8 optionally substituted alkyl, C2-C8 optionally substituted alkenyl, C2-C8 optionally substituted cycloalkyl, C3-C8 optionally substituted alkyl, optionally substituted C1-C8, C1-C8 optionally substituted aryl and C1-C8 optionally substituted R105, R106 and R107 are independently selected from hydrogen, halogen, C1-C24 optionally substituted C2-C24 optionally substituted C2-C24 optionally substituted, C3-C24 optionally substituted, C1-C24 optionally substituted C1 -C24 aryl and optionally substituted C1-C24 optionally substituted R10 is hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl and wherein "substituted" refers to the replacement of one or more hydrogen radicals in a given structure with the radical of a substituent specified selected from halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, structure I arylthioalkyl , arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, trifluoromethyl, cyano, nitro, alkylamino, arylamino, alkyla
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