Government of The United States of America; Represented by the Secretary; Department of Health and Human Services
发明人:
Greig, Nigel H.,Mattson, Mark P.,Haberman, Frank,Yu, Qian-sheng,Arumugam, Thiruma
申请号：
AU2013267082
公开号：
AU2013267082A1
申请日:
2013.12.09
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2013267082A120140109.pdf#####24 ABSTRACT Disclosed is a method of treating or preventing an oxidative stressrelated disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (1) to the mammal, wherein R1-R4 5 and X1-X3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound.Figure 1A R3 N I=o 074 R2 R Code X E R R4 m UA H H H H uric acid mUAl H H H Me 9-methyl uric acid mUA2 Me H Me H 1,7-dimethyl mic acid mUA3 Me Me Me H 1,3,7-trimethyl uric acid -H HN 3 N X I H sUA S 0 0 6-monothiouric acid sUA2 S 0 S 6,8-dithiouric acid sUA3 0 S S 2,8-dithiouric acid sUA4 S S S 2,6,8-trithiouric acid 1/7
