A mouse catching box comprises a box body (10), a lifting platform (20), and a control assembly (40). The box body (10) is provided with a trap opening (102) and a recovery opening (104). The lifting platform (20) is disposed at the bottom of the box body (10), and a mouse catching platform (30) parallel to the lifting platform (20) is disposed above the lifting platform (20). The control assembly (40) is disposed on the box body (10), and comprises a voltage measurement module (402), a controller (404), a high-voltage transformer (406), and a power grid (408). The voltage measurement module (402) transmits a triggering signal of the power grid (408) to the controller (404), and the controller (404) controls the high-voltage transformer (406) to supply power to the power grid (408). The power grid (408) comprises a positive power grid line (302) and a negative power grid line (304). The negative power grid line (304) in disconnection is divided into three segments connected respectively to a negative electrode of the high-voltage transformer (406). When a mouse connects the middle segment of the negative power grid line (304) to the positive power grid line (302), a triggering signal is generated. The mouse catching box has the following advantages: the power grid is densely arranged and the whole grid outputs a high voltage, thereby improving the efficiency for killing mice; the automatic return design of the mouse catching box makes the device automatically resets after the killing, and the mouse catching box can be continuously used to improve the long lasting effect.