An insertion portion of an endoscope includes: an image pickup unit having an observation unit and an image pickup cable; and a distal end frame member having a first hole and a second hole and having a contact surface with which a proximal end portion is brought into contact when the image pickup cable is provided in the second hole. The second hole has a shape in which the image pickup cable is rotatable together with the observation unit in a state where the image pickup cable is provided in the second hole.