Devices and methods are provided for treating a periodontal defect adjacent to a tooth, the devices and methods use a barrier configured to reduce an amount of material from entering into the periodontal defect, the barrier having a first region configured to retain a portion of the barrier against at least a portion of the tooth and a second region configured to extend over at least a portion of the periodontal defect adjacent to the tooth so as to reduce the amount of material from entering into the periodontal defect. In some embodiments, the devices and methods provided can be removed from the healed periodontal defect without the need to cut into healed soft tissue.