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METHODS FOR INHIBITING CELLULAR UPTAKE OF THE ANTHRAX LETHAL TOXIN (LT) PROTEIN COMPLEX
专利权人:
ENZO BIOCHEM; INC.
发明人:
Xiaofeng Li,DAKAI LIU,YAZHOU ZHANG,RICHARD JIN,RIDDHI BHATTACHARYYA,WEI CHENG
申请号:
US15363187
公开号:
US20170071950A1
申请日:
2016.11.29
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention identifies compounds that disrupt the interaction between anthrax proteins and LRP5/6 receptors, resulting in a reduction in anthrax toxicity. The compounds act to disrupt the intracellular transport of toxin complexes into a target cell. The present invention also provides methods for testing the effect of compounds on Wnt activity, through the use of in vitro experiments involving cells that have in at least one gene mutation involved in the Wnt pathway.
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中国工程科技知识中心
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