The present invention provides an intervention photon control method and device, wherein the method comprises: a controller controls a multi-wavelength laser light source array to output a first group of laser, and the first group of laser is exported through an optical fiber, wherein the first group of laser comprises a laser of at least one wavelength; an optical fiber coupler couples the first group of laser which is exported by the optical fiber, to obtain a to-be-output laser; and an optical fiber guide wire sends the to-be-output laser to a to-be-analyzed tissue. Therefore, through the intervention photon control method and device provided by the present invention, the multi-wavelength laser light source array can be controlled through a controller, to provide laser for therapy, and the laser is guided to a lesion site via an optical fiber guide wire in a manner of subcutaneous puncture and artery or veinous intervention.