The present disclosure discloses an ophthalmic pharmaceutical preparation as well as a preparation method and application thereof. Components of the pharmaceutical preparation are easy to obtain and are from a panax notoginseng extract. The pharmaceutical preparation is a natural traditional Chinese medicine preparation and contains the following components with a total of 45 to 95%: a notoginsenoside R1, a notoginsenoside R2, a ginsenoside Rg1, a ginsenoside Rg2, a ginsenoside Re, a ginsenoside Rb1, a ginsenoside Rb2, a ginsenoside Rd, a ginsenoside Rf, a ginsenoside Rc, a ginsenoside Rh1 and a gypenoside IX. The extract can be made into eye drops, eye ointments, eye pads, eye cream and other various dosage forms according to clinical demands. Pharmacological experiments prove that the drug is safe and effective without stimulation, and has a curative effect on damages to eyes and vision caused by eye dryness, distending pain, asthenopia, eye angiosclerosis and the like, thereby having a better clinical application prospect.
