Ying-Ju Sung;Richard Ambron;Shi-Xian Deng;Donald W. Landry
发明人:
Richard Ambron,Ying-Ju Sung,Donald W. Landry,Shi-Xian Deng
申请号：
US13569510
公开号：
US20120295853A1
申请日:
2012.08.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.
