METHODE DE DETERMINATION DE LA PRESENCE D'UNE HYPOXIE CLINIQUEMENT PERTINENTE EN CAS DE CANCER

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专利权人:

OVERGAARD, JENS;SORENSEN, BRITA SINGERS;ALSNER, JAN;WIUF, CARSTEN;NORDSMARK, MARIANNE;TOUSTRUP, KASPER

发明人:

OVERGAARD, JENS,SORENSEN, BRITA SINGERS,ALSNER, JAN,WIUF, CARSTEN,NORDSMARK, MARIANNE,TOUSTRUP, KASPER

申请号：

CA2834588

公开号：

CA2834588A1

申请日:

2012.04.30

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present invention provides a method for determining the oxygen status of a cancer of an individual. The method comprise determining the transcriptional expression level of ADM (SEQ ID No:1), and/or at least one gene selected from ANKRD37 (SEQ ID NO.: 3), P4HA2 (SEQ ID NO.: 12), NDRG1 (SEQ ID NO: 10), SLC2A1 (SEQ ID NO:15), P4HA1 (SEQ ID NO.: 11), LOX (SEQ ID NO.: 9), C3orf28 (SEQ ID NO.: 6), BNIP3L (SEQ ID NO.: 5), BNIP3 (SEQ ID NO.:4), EGLN3 (SEQ ID NO.: 7), PDK1 (SEQ ID NO.: 13), PFKFB3 (SEQ ID NO.: 14), KCTD11 (SEQ ID NO.: 8), and/or ALDOA (SEQ ID NO.: 2), in a cancer sample. The transcriptional level is then correlated to the transcriptional level to at least one reference gene, and oxygen status10 is then evaluated by comparing the correlated transcription level with a predetermined reference sample comprising cancer cells characterized by a high oxygen level.

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