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Pyridazinone derivatives as PARP inhibitors
专利权人:
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.
发明人:
Jones, Philip,Dessole, Gabriella,Schultz-Fademrecht, Carsten,Muraglia, Ester,Kinzel, Olaf,Branca, Danila,Ferrigno, Federica,Lillini, Samuele,Pescatore, Giovanna
申请号:
AU2008322676
公开号:
AU2008322676B2
申请日:
2008.11.14
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention relates to compounds of formula (I): and pharmaceutically acceptablesalts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP)and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries,ischaemic conditions, stroke, renal failure, cardiovascular diseases, vasculardiseases other than cardiovascular diseases, diabetes mellitus, neurodegenerativediseases, retroviral infections, retinaldamage, skin senescence and UV-inducedskin damage, and as chemo-or radiosensitizers for cancer treatment.
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