NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS
The Invention relates to products of formula (1) wherein = represents a simple link or double； ra represents h, Hal, alkoxy, or cycloalkyl, heteroaryl phenyl, nhcoalk, nhcocicloalk or nr1r2； X represents o or NH, OsO2； a represents H or s； W represents Cor, R represents alkyl or cicloal Chyle； alkyl alkoxy optionally substituted with Hydroxy phenyl nr3r4,,,,Alkoxy optionally substituted heteroaryl or hetrocicloalquilo； with nr3r4, i.e. a radical or - N - (CH2) nr3r4, a radical, or or or - phenyl - (CH2) n - phenyl, phenyl optionally substituted, and N = 1A4； or the radical nr1r2； R1 and R2 represents H or ALK represents h, cycloalkyl or r3yr4 represents h, alkyl, ALK, Ci Cloalquilo, phenyl or heteroaryl； or r2y / R1, R3, R4 form a cycle containing N or s, Optionally,N and / or NH； being all heterocicloalquilo, phenyl optionally substituted heteroaryl and cyclic； While these products in All Forms is u00d3meras and salts, such as medication primarily as inhibitors of met.Pronalazak se odnosi na nove proizvode formule (I): gd e - - - - je jednostruka ili dvostruka veza, Ra = H, Hal, alkoksi, O-cikycloalkil, heteroaril,. fenil, NHCOalk, NHCOcikloalk ili NR1 R2； X = S, SO ili S02； A = NH or S； W = H, alkil ili COR gde R = cikloalkyl； alkil, po izboru supstituisan sa NR3R4, alkoksi, hidroksi, fenil, heteroariyl, ili heterocikloalkil； alkoksi op izboru supstituisan sa NR3R4, odnosno 0-(CH2)n-NR3R4 grupa, O-fenil ili 0-(CH2)n-fenil grupa, gde je fenil po izboru supstituisan i n= 1 do 4； gde u NR1 R2 grupi； R1 = H ili alk i R2 = H, cikloalkil ili alkil； R3 i R4 = H, alk, cikloalkil, heteroaril ili fenil, R1, R2 i/ili R3. R4 formiraju prsten sa koji N po izoru sadrži O, S, N i/ili NH； svi heterocikloalkil, heteroaril i fenil i ciklične grupe su po izboru supstituisane, dati proizvodi su u svim izomernim oblicima i svim solima kao lekovi, posebno kao inhibizori MET-a.
