IFOM FONDAZIONE INSTITUTO FIRC DI ONCOLOGIA MOLECOLARE
发明人:
NICOLAI SIDENIUS
申请号：
BR112013016107
公开号：
BR112013016107A2
申请日:
2011.12.21
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention relates to inhibitors of the urokinase-type plasminogen activator receptor (uPAR). The generated inhibitors are bivalent uPAR-ligands containing the receptor binding domains of the extracellular protease urokinase-type plasminogen activator (uPA) and of the extracellular matrix protein vitronectin (VN), in different configurations, linked by a scaffold. The present invention also refers to the above molecules for use as a medicament, in particular for treatment of cancer, and for diagnostic purposes.
