compound, pharmaceutical composition, methods to treat a neurodegenerative disease, and to reduce the concentration of p-cjun in brain tissue of an individual in need of it, use of a compound, and, in vitro method
Andrei W. Konradi,Anh Truong,Gary D. Probst,Gergely Toth,HING L. SHAM,Jennifer Sealy,R. Jeffrey Neitz,Roy K. Hom,Simeon Bowers
申请号：
BRPI1007923
公开号：
BRPI1007923A2
申请日:
2010.02.05
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
compound, pharmaceutical composition, use of a compound, and in vitro method to measure phosphorylated kinase substrate the present disclosure obtains inhibitors of c-jun-n-terminal kinases (jnk) having a structure according to the following formula (i ): or a salt or solvate thereof, in which ring a, ca, cb, z, r5, we cy are defined here. the disclosure further obtains pharmaceutical compositions including the compounds of the present disclosure and provides methods of preparing and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as alzheimer's disease.composto, composição farmacêutica, uso de um composto, e, método in vitro para medir substrato de quinase fosforilado a presente revelação obtém inibidores de c-jun-n-terminal-quinases (jnk) tendo uma estrutura de acordo com a seguinte fórmula (i): ou um seu sal ou solvato, na qual o anel a, ca, cb, z, r5, w e cy são aqui definidos. a revelação adicionalmente obtém composições farmacêuticas incluindo os compostos da presente revelação e fornece métodos de preparar e de usar os compostos e as composições da presente revelação, e.g., no tratamento e na prevenção de vários distúrbios, tal como mal de alzheimer.
