PROBLEM TO BE SOLVED: To obtain a preparation which promotes production of metallothionein, improves resistivity to oxidation stress in an organism, and prevents skin damage caused by ultraviolet rays or the like.SOLUTION: The inventor confirmed that pearl-derived and/or nacre-derived hydrolyzed protein promoted metallothionein production and was effective as an external preparation for the skin.【課題】本発明の目的はメタロチオネインの産生を促進し、生体内の酸化ストレスに対する抵抗性が向上して、紫外線等による皮膚傷害を防ぐ製剤を得ること。【解決手段】真珠及び／又は真珠層由来蛋白加水分解物がメタロチオネイン産生を促進し、皮膚外用剤として有効なことを確認した。【選択図】図１
