Jsou popsány farmaceutické kombinace sloučeniny 1 a látky vybrané z cisplatiny, protilátky C225 imunospecifické pro EGFR, anti-VEGF, ZDG474, SU6668 a capecitabinu a způsoby vhodné pro léčení a prevenci proliferačních poruch.In the present invention, there are described pharmaceutical combinations of the compound 1, being selected from the group consisting of Cisplatin the antibody C225 immunospecific for the EGFR, anti-VEGF, ZDG474, SU6668 and capecitabine, and methods suitable for the treatment and prevention of proliferative disorders.