METHOD FOR PREPARING A PURIFIED EXTRACT OF LONICERA JAPONICA THUNBERG AND THE COMPOSITION COMPRISING THE SAME FOR PREVENTING AND TREATING SEPSIS AND SEPTIC SHOCK
Sung-Tae Yoon,Jeong Hoon Kim,Bang Ho Lim,Young Mok Kim,Sung Hum Yeon,Hyun Soo Kim,Sun-Mee Lee
申请号：
US14397468
公开号：
US20150044316A1
申请日:
2012.11.01
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a method for preparing a purified extract of Lonicera Japonica THUNBERG and the composition comprising the same for preventing and treating sepsis and septic shock. The purified extract of purified extract of Lonicera Japonica THUNBERG potent antisepsis activity in severe sepsis CLP model test, the effect on MODS, and the inhibitory effect on various pro-inflammatory cytokines such as TNF-alpha, IL-1beta, IFN-gamma, HMGB-1 etc, as well as it showed unexpectedly synergistic effect on the treatment of sepsis and septic shock in case of combining with the commercially available anti-septic agent such as broad-spectrum anti-biotic to the person skilled in the art, therefore, it can be useful in treating and preventing the sepsis and septic shock as a medicament and health functional food.
