PROBLEM TO BE SOLVED: To provide a therapeutic agent for inflammatory diseases based on inhibition of binding between cholesterol crystals and a receptor which is identified as a pattern recognition receptor which recognizes the cholesterol crystals.SOLUTION: The therapeutic agent for inflammatory diseases contains as an active ingredient an expression inhibitor of Macrophage-inducible C-type lectin (Mincle), a specific binding substance for Mincle or a specific binding substance for cholesterol crystals, and inhibits the binding between Mincle and the cholesterol crystals.SELECTED DRAWING: Figure 24【課題】コレステロール結晶を認識するパターン認識受容体を同定し、コレステロール結晶と当該受容体との結合の阻害に基づく炎症性疾患の治療剤を提供する。【解決手段】Ｍａｃｒｏｐｈａｇｅ－ｉｎｄｕｃｉｂｌｅ Ｃ－ｔｙｐｅ ｌｅｃｔｉｎ（Ｍｉｎｃｌｅ）の発現阻害物質、Ｍｉｎｃｌｅに対する特異的結合物質又はコレステロール結晶に対する特異的結合物質を有効成分とし、Ｍｉｎｃｌｅとコレステロール結晶との結合を阻害する、炎症性疾患の治療剤。【選択図】図２４
