HENRY FORD HEALTH SYSTEMS;STEALTH PEPTIDES INTERNATIONAL, INC.
发明人:
D. TRAVIS WILSON,HANI N. SABBAH
申请号：
BR112015009072
公开号：
BR112015009072A2
申请日:
2013.10.22
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract the disclosure provides methods of preventing or treating heart failure in a mammalian subject, reducing risk factors associated with heart failure, and / or reducing the likelihood or severity of heart failure. the disclosure also provides methods of preventing, or treating lv remodeling in a mammalian subject, and / or reducing the likelihood or severity of lv remodeling. the methods comprising administering to the subject an effective amount of an aromatic-cationic peptide. in some embodiments, the methods comprising administering to the subject an effective amount of an aromatic cationic peptide to reduce levels of c-reactive protein, tumor necrosis factor alpha, interleukin 6, reactive oxygen species, nt-pro bnp, and / or cardiac troponin i, and / or reduce expression levels of mlcl at 1 and / or alcat 1 in subjects in need thereof. in some embodiments, the methods comprising administering to the subject an effective amount of an aromatic cationic peptide to increase expression of taz1 and / or increase mk atp activity in subjects in need thereof. _____________________________________________________________________________________________________ patent summary: "methods for reducing the risks associated with heart failure and associated factors". The invention provides methods of preventing or treating heart failure in a mammalian subject, reducing risk factors associated with heart failure, and / or reducing the likelihood or severity of heart failure. The invention also provides methods of preventing or treating ve remodeling in a mammalian subject and / or reducing the likelihood or severity of ve remodeling. The methods comprise administering to the individual an effective amount of a cationic aromatic peptide. In some embodiments, the methods comprise administering to the subject an effective amount of a cationic aromatic peptide to reduce levels of c-reactive protein, tumor necrosis factor alpha, interleukin 6, reactive oxygen species, nt-pro b
