對於共刺激TNF受體具四價之雙特異性抗體农业专利-农业专业知识服务系统

发明人:: AMANN, MARIA,阿曼　玛丽亚,阿曼　瑪麗亞,BRUENKER, PETER,布恩克　彼德,CLAUS, CHRISTINA,克劳斯　克莉丝汀娜,克勞斯　克莉絲汀娜,FERRARA KOLLER, CLAUDIA,伏拉拉　寇勒　克劳蒂亚,伏拉拉　寇勒　克勞蒂亞,GRAU-RICHARDS, SANDRA,葛洛－瑞秋　珊卓,HOSSE, RALF,荷斯　劳福,阿曼玛丽亚,阿曼瑪麗亞,布恩克彼德,克劳斯克莉丝汀娜,克勞斯克莉絲汀娜,伏拉拉寇勒克劳蒂亚,伏拉拉寇勒克勞蒂亞,葛洛-瑞秋珊卓,荷斯劳福

摘要：: The invention relates to novel bispecific antigen binding molecules, comprising (a) four moities capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.本發明係關於新穎雙特異性抗原結合分子，其包含(a)能夠特異性結合於共刺激TNF受體家族成員之四個部分體，(b)至少一個能夠特異性結合於目標細胞抗原之部分體，及(c)由能夠穩定結合之第一子單元及第二子單元構成之Fc結構域，且係關於製造此等分子之方法及其使用方法。