A gastrointestinal tract diagnosis device, comprising: an endoscope (10) having a substrate (122) and a control unit (1220) and a recognition marker (1220) therein an image capturing module (13)including a first lens (131) and an image sensor (131a) that are disposed on the substrate (122) an illuminating module (14) including a first light source (141) disposed on the substrate (122) an enclosure body (15) assembled to a connection device (17) to waterproofingly enclose the image capturing module (13)and the illuminating module (14) and a work station (30) connecting to the endoscope (10) to access the recognition marker (1220) to add a machine identity into the recognition marker (1220) to match with the endoscope (10), wherein the work station (30) determines if a usage state of the endoscope (10) is overdue the work station (30) determines if the endoscope (10) has connected to an another work station (30) different from the work station (30) by the recognition marker (1220) and the machine identity. A control method based on the above device is also provided.