NARKUNAN, Kesavaram,CHEN, Xinghai,KOCHAT, Harry,HAUSHEER, Frederick
申请号：
HUE07852779
公开号：
HUE031374T2
申请日:
2007.10.16
申请国别(地区):
HU
年份:
2017
代理人:
摘要：
The novel C10-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells in vitro； (ii) are potent inhibition of Topoisomerase I； (iii) lack of susceptibility to MDR/MRP drug resistance； (iv) require no metabolic drug activation: (v) lack glucuronidation of the A-ring or B-ring； (vi) reduce drug-binding affinity to plasma proteins； (vii) maintain lactone stability； (viii) maintain drug potency； and (ix) possess a low molecular weight (e.g., MW<；600).
