A needleless access vial includes a vial body for storing a liquid medication. A needleless access port is disposed within an opening along the top of the vial body. A valve having a deformable body is positioned within the access port housing, and is in communication with the access port inlet section and the access port outlet section. The valve is biased toward a closed configuration, and transitions to an open configuration upon engagement of the outlet section by a needleless syringe.