Conjugates and preparation and use thereof

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专利权人:

Suzhou Ribo Life Science Co.; Ltd.

发明人:

ZHANG, Hongyan,YANG, Zhiwei,CAO, Liqiang,WAN, Liangyi

申请号：

AU2018394875

公开号：

AU2018394875A1

申请日:

2018.11.29

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Disclosed are a compound for forming a conjugate with an active agent such as an oligonucleotide having a structure represented by Formula (321), and a corresponding conjugate. The conjugate can specifically target hepatocytes, thereby effectively solves the problems associated with delivery of oligonucleotide drugs in vivo, and has low toxicity and excellent delivery efficiency while maintaining high stability for the delivered oligonucleotide.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/