RALF ALTENBURGER,MAGGY BABIOLE SAUNIER,NICOLE BARGENDA,MICHAELA ANNA MARIA BOCK,SABINE ADLER,BRUNO BUSS,CATHERINE CURDY,INDRAJIT GHOSH,STEFAN HIRSCH,PATRICE FRANCOIS KELLER,CHARU KOCHHAR,SHOUFENG LI,N
申请号：
BRPI0817442
公开号：
BRPI0817442A2
申请日:
2008.09.24
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical oral fixed dose combination comprising a) a therapeutically effective amount of Aliskiren, or a pharmaceutically acceptable salt thereof, b) a therapeutically effective amount of Valsartan, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical oral fixed dose combination shows an in vitro dissolution of component a) of 80% or less after 10 minutes and 98% or less after 20 minutes, and a dissolution profile of component b) of 25% or more after 30 minutes, and 40% or more after 60 minutes at pH 4.5.
