Neil James Gallagher,John Francis Lyons,Neil Thomas Thompson,Stephen Murray Yule,Christopher William Murray
申请号：
US12445141
公开号：
US08277807B2
申请日:
2007.10.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I):or salts, tautomers, solvates and N-oxides thereof wherein R1 is hydroxy or hydrogen R2 is hydroxy methoxy or hydrogen provided that at least one of R1 and R2 is hydroxy R3 is selected from hydrogen halogen cyano optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy R4 is selected from hydrogen a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members halogen cyano hydroxy amino and optionally substituted mono- or di-C1-5 hydrocarbyl-amino or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 inhibitors.
