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Mixed immunoglobulins containing non cucumber binding
专利权人:
Biomolecular Holdings LLC
发明人:
Capon, Daniel J.
申请号:
ES14763801
公开号:
ES2759061T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
The present invention provides compounds, and methods for producing compounds having the structure:wherein A is a first polypeptide component of the compound; wherein C is a second polypeptide component of the compound, which polypeptide component comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an F<;sub>;c<;/sub>;domain of an antibody; (ii) bind to an F<;sub>;c<;/sub>;receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine, selenocysteine, CP, CPXCP (where X = P, R, or S), CDKTHTCPPCP, CVECPPCP, CCVECPPCP and CDTPPPCPRCP, wherein B is a chemical structure linking A and C; wherein the dashed line between B and C represents a peptidyl linkage; wherein the solid line between A and B represents a nonpeptidyl linkage comprising the structure:
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