Disclosed herein are uses of a mammalian target of rapamycin (mTOR) inhibitor and chloroquine or analogue thereof in the manufacture of a medicament for treating cancer patients who are not responsive to a hormone therapy and an immunotherapy. In particular, the medicament is used during the hormone therapy and the immunotherapy to sensitize the patients to the hormone therapy and the immunotherapy.本揭示內容係有關於哺乳類雷帕黴素靶蛋白（mTOR）抑制劑及氯喹或其類似物於製備一藥物之用途，其中該藥物可用以治療對一荷爾蒙治療及一免疫治療無產生反應的癌症病患。具體來說，該藥物係用於在對病患投予荷爾蒙治療及免疫治療期間，使該病患對荷爾蒙治療及免疫治療增加敏感性。
