The present invention provides a composition comprising a chemokine polypeptide which is a chemokine or a receptor binding domain thereof and a cytokine polypeptide which is an interleukin, a TNF-superfamily cytokine or a receptor binding domain thereof wherein the chemokine polypeptide and the cytokine polypeptide have a target cell in common, and the combination has an enhanced chemokine activity as compared to the chemokine polypeptide, and an enhanced cytokine activity as compared to the cytokine polypeptide. The present invention also provides a method for enhancing cytokine activity, comprising: administering to a subject in need thereof a cytokine polypeptide in combination with a chemokine polypeptide, wherein: the cytokine polypeptide is an interleukin, a TNF-superfamily cytokine or a receptor binding domain thereof the chemokine polypeptide is a chemokine or a receptor binding domain thereof and the chemokine polypeptide and the cytokine polypeptide have a target cell in common.本發明提供一種組合物,其包含:趨化素多肽,其為一趨化素或其受體結合域;和細胞素多肽,其為一介白素、一TNF-超家族細胞素或其受體結合域;其中該趨化素多肽和該細胞素多肽具有共同的標的細胞,且該組合物具有相較於該趨化素多肽單獨施用時的增進的趨化素活性,以及相較於該細胞素多肽單獨施用時更增進的細胞素活性。本發明亦提供一種增進細胞素活性的方法,其包含:將細胞素多肽與趨化素多肽共同施用,其中:該細胞素多肽為一介白素、一TNF-超家族細胞素或其受體結合域,該趨化素多肽為一趨化素或其受體結合域;且該細胞素多肽和該趨化素多肽具有共同的標的細胞。
