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Aminopyridine derivatives having aurora a selective inhibitory action
专利权人:
Hayley Binch
发明人:
Hayley Binch,Masaya Hashimoto,Michael Mortimore,Mitsuru Ohkubo,Tomoko Sunami
申请号:
US13259620
公开号:
US08367690B2
申请日:
2010.03.15
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10 R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11 R10 is F, Cl, CF3, or C1-2 alkyl R11 is halogen atom, hydroxy, or cyano W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.
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