因子VIII-XTEN融合物及其用途农业专利-农业专业知识服务系统

发明人:: LIU, TONGYAO,刘　彤瑶,劉　彤瑤,CHANG, PEI YUN,章佩云,章佩雲,KULMAN, JOHN,库门　约翰,庫門　約翰,SCHELLENBERGER, VOLKER,薛伦贝格尔　沃克,薛倫貝格爾　沃克,JIANG, HAIYAN,蒋　海燕,蔣　海燕,PETERS, ROBERT T.,彼得斯　罗伯特,彼得斯　羅伯特,CHHABRA, EKTA SETH,乔巴拉　艾可塔,喬巴拉

摘要：: The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.本發明提供包含因子VIII(FVIII)多肽及XTEN多肽之嵌合蛋白。該FVIII多肽可對馮威里氏因子(VWF)具有較小親和力。將適當尺寸之XTEN多肽插入該FVIII多肽中特定位置以延長該FVIII多肽之半衰期。本發明亦包括核苷酸、載體、宿主細胞及使用該等嵌合蛋白例如以治療出血疾病及病症之方法。