Incorporation of the B18R gene to enhance antitumor effect of virotherapy

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专利权人:

Xiaoliu Zhang

发明人:

Xiaoliu Zhang,Xinping Fu

申请号：

US13420734

公开号：

US20120237481A1

申请日:

2012.03.15

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to a novel composition and method to potentiate the antitumor effect of an oncolytic virus by providing for resistance against a hosts innate interferon response. Particularly, a B18R gene is incorporated into an oncolytic virus. During treatment of a host with the modified oncolytic virus, the oncolytic virus retains its phenotype, and the hosts innate immune response has a minimal affect on viral replication.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/