Disclosed are compounds of the formula (I): where in R, R, R and R are independent l y hydrogen, C -C alkyl, halo, a sulfate, a glucuronide, -OH, a bulky group, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, N ( CH ) ； a phosphate group, and a phosphinate group； R is hydrogen, halogen or alkyl； R11 i s selected from the group consisting of H, C -C alkyl, halogen, a sulfate, a glucoronide, - SONH, -COOH, -CN, -CHCN-, -NHCN-, -CHO, =CHOCH, -COO salt, -0S0alkyl, -NH, and -NHCO ( CH ) n； R is selected from the group consisting o f H, a C -C alkyl, a sulfate, a glucoronide, a bulky group, aryl, cycloalkyl, heteroaryl and heterocycloalkyl； X i s selected from the group consisting of C -C alkyl, C -C alkenyl, C -C alkynyl, halogen, a glucoronide, -NH, - SONH, -COOH, -CN, -CHCN, -NHCN, -CHO, -COOsalt, -0S0alkyl, - SH, - SCH, -CH [ ( CH ) CH ] COOCH, - ( CH ) mCOOCH, - ( CH U-O-CH, - ( CH ) m-0- ( CH ) CH, ( CH) - S -CH, - ( CH U- S - ( CH )CH, - ( CH ) -NH- ( CH ) CH, -C -C alkenyl -0- ( CH ) CH, - C -C alkenyl - S - ( CH ) CH, -C -Calkenyl -N- ( CH ) CH, -C -C alkynyl -O- ( CH ) CH, -C -C alkynyl - S - ( CH ) CH, -C-C alkynyl -N- ( CH ) CH, - ( CH U-OH, - ( CH ) -O-NH, - ( CH) - S -NH, -NH ( CH ) CH, -NH ( CH ) OCH, -NH ( CH ) CHOH-COOH, -N ( CH ), - ( CH ) (NH ) CHOH, -NHCOOH, - ( CH ) NHCOOH, -NO, - SCN, - S0alkyl, -B ( OH ) , - ( CH ) N ( CH ) - SO-NH, - ( CH ) -NH- SO -NH,-NHC ( = S) CH, and -NHNH； and Y is selected from hydrogen, =0, -OCO(R) and -OH； wherein m is an integer between 0-20, n is an integer between 0-8, the symbol represents either a single or a double bond capable of forming a keto group at position 3 or 17； and the &Lambda；/WV symbol represents any type of bond regardless of the stereochemistry； and the respective enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds. The compounds are useful in the treatment of various types of cancer.
