A device for minimally invasive bone harvesting surgery described herein includes a cutter, a sleeve, and a drive control system. The cutter includes a head and a spiral conveying portion. An external screw thread is disposed on a surface of the spiral conveying portion, the sleeve is sleeved on the cutter, and the head and at least a part of the screw thread of the surface of the spiral conveying portion are exposed from the sleeve. The drive control system drives and controls the cutter to work. The device for minimally invasive bone harvesting surgery in this invention only needs a very tiny skin incision and bone window, cuts or grinds cancellous bone to bone fragments and then conveys them through a screw thread channel, which realizes the oriented conveying of the harvested bone.