The present invention relates to a SOST antibody, antigen-binding fragments, and pharmaceutical use thereof. Specifically, the present invention relates to humanized and chimeric antibodies specifically binding to SOST antibody, and the humanized antibodies and chimeric antibodies are characterized by a high affinity, high efficacy, prolonged half-life, high solubility and good stability. In particular, the present invention can be used to increase bone mass, bone mineral density and bone strength, and it can be used in the treatment of human bone metabolism related diseases, such as osteoporosis, etc.本發明涉及抗硬骨素抗體、其抗原結合片段及其醫藥用途。具體地，本發明提供特異性結合人硬骨素的人源化抗體和嵌合抗體，並且該人源化抗體和嵌合抗體的特徵在於具有高親和力、高藥效、延長半衰期和高溶解度、穩定性好等特點。本發明的抗體可用於增加骨量、骨礦物質密度和骨強度，並可用於治療人骨代謝相關疾病如骨質疏鬆症等。
