A system for assisting a manual filling of at least two dose packs laid on a support surface wherein each said dose pack has receptacles adapted to receive medication items based on dose pack prescription profiles. The system generally has a dose pack medication localizer for determining a location of each receptacle of each said dose pack, and for identifying medication items required in each said receptacle using the dose pack prescription profiles； a medication grouper for grouping, for each of the medication items of the dose pack prescription profiles of all of the dose packs, the locations of each said receptacle to be filled with a corresponding one of the medication items； a distribution matrix generator for generating a distribution sequence for filling the dose packs using each one of said grouping； and an output for producing a visual representation of the distribution sequence.
