A pharmaceutical composition for treating cancer in an individual, comprising at least a pharmaceutically effective amount of a novel target HCC reversal signal substance, and a pharmaceutically acceptable ingredient comprising a vehicle, a carrier, a diluent or an excipient and the novel target HCC reversal signal substance is a mixture that consisting of antroquinonol (AQL), antrocinnamonin A (ACA), antroquinonol B (AQB), antroquinonol D (AQD), dehydroeburicoic acid (DEA), dehydrosulphurenic acid (DSA), zhankuic acid A (ZAA), zhankuic acid C (ZAC), antcin K (ANK), antcin C (ANC) in which the ratio among each component of the pharmaceutical composition may be adjustable depending on the type of cancer wherein the pharmaceutical composition is used for cancer suppression activity of which comprises at least one selected from human breast cancer cell line MCF-7, human hepatoma cell line HepG2, human colorectal cancer cell line HCT116, human colon cancer cell line RKO, human tissue leukocyte cell line U937, and pre-human myeloid white blood cell line HL-60.
