The present invention discloses the equipment that one kind enters the transdermal flux of penetrant through at least one formation path of the skin layer across subject in subject's body. The equipment includes a transmission reservoir, the transmission reservoir includes: an i) nonbiodegradable matrix, the nonbiodegradable matrix has a bottom surface and the what Medium Culture defines plurality of conduits, and at least part of the plurality of conduits is connected to the bottom surface； And ii) a undissolved hydrophilic osmotic object, in at least part for setting the plurality of conduits of what matrix, wherein when the bottom surface of matrix is located at least one forms path and is in fluid communication with this when, hydrophilic osmotic object can be contacted with the subcutaneous fluid of subject. Also at least one formation path that disclosing makes the transdermal flux of penetrant pass through the skin layer across subject enters the system and method in subject's body.本發明揭示一種使滲透物之經皮流量經穿過受試者之皮膚層之至少一個形成路徑進入受試者體內之設備。該設備包含一傳送儲集層，該傳送儲集層包含：i)一非生物可降解基質，該非生物可降解基質具有一底表面且於該基質內界定複數個管道，該複數個管道之至少一部分與該底表面連通；及ii)一未溶解親水性滲透物，其置於基質之複數個管道之至少一部分中，其中當基質之底表面經定位與該至少一個形成路徑流體連通時，親水性滲透物可與受試者之皮下流體接觸。亦揭示使滲透物之經皮流量經穿過受試者之皮膚層之至少一個形成路徑進入受試者體內之系統及方法。
