18f-fluciclovine compositions in citrate buffers

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专利权人:

GE HEALTHCARE LIMITED

发明人:

ROMOREN KRISTINE,RYAN OLAV

申请号：

NZ62425012

公开号：

NZ624250A

申请日:

2012.12.21

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed herein are pharmaceutical compositions comprising [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid ([18F]FACBC, commonly known as [18F]-Fluciclovine), and a 50-100 mM citrate buffer and having a pH between 4 and 5 which provides for decreased radiolysis, and not more than 150 µg/mL 1-amino-3-hydroxyl-cyclobutane-1-carboxylic acid (hydroxyl-ACBC). Also disclosed is a method to obtain said pharmaceutical composition.

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