Paul Lobben,Rulin Zhao,Bei Wang,Bang-Chi Chen,Shuang Liu,Min Hu,Yuh-Lin Allen Yang,Matthew Isherwood,Rasidul Amin,Wenge Cui
申请号：
US12995776
公开号：
US08420811B2
申请日:
2009.06.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. One such intermediate has the following structure:
