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COMPOSÉ HÉTÉROCYCLIQUE AZOTÉ, PROCÉDÉ DE PRÉPARATION, INTERMÉDIAIRE, COMPOSITION ET APPLICATION
专利权人:
Ltd.;Shanghai Pharmaceuticals Holding Co.
发明人:
申请号:
EP18850013.6
公开号:
EP3677583A1
申请日:
2018.08.31
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. (I)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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