CHOI, YOUN WOONG,MIN, BYUNG GU,KI, DO HYOUNG,JUN, HYUNG JOON,CHOI, EUN-JUNG,CHO, SANG MIN,HA, DAE-CHUL,PARK, HEE-CHAN,SONG, HEE-YONG
申请号：
PH12016500414
公开号：
PH12016500414A1
申请日:
2016.03.03
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention relates to a solid preparation comprising choline alfoscerate and calcium silicate and a method for preparing the same, wherein calcium silicate adsorbs choline alfoscerate and thereby enables formulation in a solid form. Compared to soft capsule formulations, the solid preparation of the present invention, comprising choline alfoscerate and calcium silicate, has advantages of there being less concern regarding deterioration due to microorganisms and stability degradation due to moisture, and of being excellent in the ease of dosing because of a smaller volume. In addition, the present invention improves the initial dissolution rate of the solid preparation by using two or more disintegrants by mixture and thereby exhibits the same level of dissolution profile as conventional soft capsule formulations, and therefore is not different therefrom in the expression of a medicinal effect.
